Andrea LaCroix PhD
Dr. LaCroix received her PhD in Epidemiology from the University of North Carolina at Chapel Hill and completed a postdoctoral fellowship in cardiovascular disease at The Johns Hopkins University. Dr. LaCroix came from the Fred Hutchinson Cancer Research Center, Public Health Sciences Division where she led many activities for the Women's Health Initiative Clinical Coordinating Center for more than 17 years. She was also a faculty member at the University of Washington (UW) from 1989 to 2013 and a Senior Scientific Investigator at the Group Health Research Institute. Dr. LaCroix's research focuses on the identification of behavioral, pharmaceutical, biomarker, and genetic factors related to the development of chronic diseases including cancer, cardiovascular disease, and fracture outcomes. Dr. LaCroix specializes in the health of postmenopausal and older women and has built and sustained a research program that spans the broad areas of etiologic epidemiologic studies, improving health services and testing preventive interventions that have improved public health and clinical care for women across the lifespan. As a clinical trialist, Dr. LaCroix has been the Seattle Principal Investigator for several major trials testing preventive interventions for fracture including the Fracture Intervention Trial and the PEARL Trial. In addition to WHI, she leads the Data Coordinating Center for the Menopause Strategies: Finding Lasting Answers for Symptoms and Heath (MsFLASH), a U01 multidisciplinary network of clinical trialists which has conducted 4 clinical trials testing 7 interventions for relief of menopause symptoms over the past 6 years. She has served on the National Advisory Council on Aging, the Clinical Trials Advisory Panel and chaired the BCA-B Study Section for NIA. In 2010, she was the recipient of the McDougall Mentoring Award for her development of postdoctoral fellows within her T32 training program entitled, "Improving Health Care for Aging Women." Dr. LaCroix is Director of UCSD's Women's Health Center of Excellence that launched in December 2013 and the author of 300 publications.
9500 Gilman Dr. #0725
La Jolla, CA, CA 92093-0725
LaCroix AZ, Powles T, Osborne CK, Wolter K, Thompson JR, Thompson DD, Allred C, Armstrong R, Cummings SR, Eastell R, Ensrud KE, Goss P, Lee A, Neven P, Reid DM, Curto M, Vukicevic S, on behalf of the PEARL Investigators. Breast cancer incidence in the PEARL Trial of lasofoxifene in postmenopausal osteoporotic women. J Natl Cancer Inst 2010;102(22):1706-1715.
Freeman EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H, Carpenter JS, Anderson GL, Larson JC, Ensrud KE, Reed SD, Newton KM, Sherman S, Sammel MD, LaCroix AZ. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA 2011;305(3):267-274. [PMCID: PMC3129746]
LaCroix AZ, Chlebowski RT, Manson JE, Aragaki AK, Johnson KC, Martin L, Margolis KL, Stefanick ML, Brzyski R, Curb JD, Howard BV, Lewis CE, Wactawski-Wende J; for the WHI Investigators. Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA 2011;305(13):1305-1314. [NIHMS463660]
LaCroix AZ, Freeman EW, Larson J, Ensrud KEE, Carpenter J, Joffe H, Cohen L, Reed S, Seguin R, Sternfeld B. Effects of escitalopram on menopause-specific quality of life and pain in healthy menopausal women with hot flashes: a randomized controlled trial. Maturitas 2012;73(4):361-368. [NIHMSID: 413869]
Cohen LS, Joffe H, Guthrie KA, Ensrud KE, Freeman M, Carpenter JS, Learman LA, Newton KM, Reed SD, Manson JE, Sternfeld B, Caan B, Freeman EW, LaCroix AZ, Tinker LF, Laforce CB, Larson JC, Anderson GL. Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial. Menopause 2013 Aug 26. [Epub ahead of print] PubMed PMID: 23982113.
Sternfeld B, Guthrie KA, Ensrud KE, LaCroix AZ, Larson JC, Dunn AL, Anderson GL, Seguin RA, Carpenter JS, Newton KM, Reed SD, Freeman EW, Cohen LS, Joffe H, Roberts M, Caan BJ. Efficacy of exercise for menopausal symptoms: a randomized controlled trial. Menopause 2013 Aug 12. [Epub ahead of print] PubMed PMID: 23899828.
Newton KM, Reed SD, Guthrie KA, Sherman KJ, Booth-Laforce C, Caan B, Sternfeld B, Carpenter JS, Learman LA, Freeman EW, Cohen LS, Joffe H, Anderson GL, Larson JC, Hunt JR, Ensrud KE, Lacroix AZ. Efficacy of yoga for vasomotor symptoms: a randomized controlled trial. Menopause. 2013 Sep 16. [Epub ahead of print] PubMed PMID: 24045673; PubMed Central PMCID: PMC3871975.
LaCroix AZ, Jackson RD, Aragaki A, Kooperberg C, Cauley JA, Chen Z, Leboff MS, Duggan D, Wactawski-Wende J. OPG and sRANKL serum levels and incident hip fracture in postmenopausal Caucasian women in the Women's Health Initiative Observational Study. Bone 2013 Oct;56(2):474-81. Epub 2013 Jun 2. PubMed PMID: 23735608.
Rillamus-Sun E, LaCroix AZ, Waring ME, Kroenke CH, LaMonte MJ, Vitolins MZ, Seguin R, Bell CL, Gass M, Manini TM, Masaki KH, Wallace RB. Obesity and the probability of living to age 85 without major disease or disability in older women. JAMA Intern Med 2014 Jan 1;174(1):98-106. doi: 10.1001/jamainternmed.2013.12051. PubMed PMID: 24217806.
Beasley JM, Wertheim BC, LaCroix AZ, Prentice RL, Neuhouser ML, Tinker LF, Kritchevsky S, Shikany JM, Easton C, Chen Z, Thomson CA. Biomarker-calibrated protein intake and physical function in the Women’s Health Initiative. J Am Geriatr Soc. 2013 Nov;61(11):1863-71. doi: 10.1111/jgs.12503. Epub 2013 Oct 28. PubMed PMID: 24219187.
Seguin R, Buchner DM, Liu J,Allison M, Manini T, Wang C-Y3 Manson JE, Messina CR, Patel MJ, Moreland L, Stefanick ML, LaCroix AZ. Sedentary behavior and mortality in older women: findings from the Women’s Health Initiative. Am J Prev Med 2014; in press.
Education & Certifications
PhD in Epidemiology, July 1984
University of North Carolina, Chapel Hill, N.C.
Dissertation Topic: Occupational Characteristics and Development of Coronary Heart Disease
MPH in Public Health Nursing, August 1981 University of North Carolina, Chapel Hill, N.C.
B.S.N., May 1979 (Magna cum laude) Georgetown University, Washington, D.C.
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